Ex vivo ELECTROPHYSIOLOGY - Ingénierie Cellulaire et Vectorologie

Patch clamp recordings are combined to diverse tools to investigate neuronal microcircuits activity

Experimental models

Rodent brain slices	Zebrafish Larva

• Intrinsic membrane properties

• Action potential firing and excitability

• Microcircuit synaptic connectivity

• Synaptic plasticity

• Ion channel biophysical properties

• Morphological neuron reconstruction

• Mechanisms of basic neuronal processes

• Functional mechanisms underlying/related pathological disorders

• Therapeutic perspective for human cognitive or neurological impairments

• Developmental profile of neuronal properties and activity

• Pharmacology

Characterization of preclinical models recapitulating human disease

Functional and morphological alterations in a mouse model of epilepsy Publication

Optogenetics

Activation of light-sensitive ion channels (opsins) to control neuron activity Publication